Advantages of CCC

From TheLiquidPhase

Modern CCC technology has many advantages over traditional preparative techniques:

Fast

CCC provides high throughput preparative separations.

Inexpensive

After the purchase of the machine the only running costs are that of the solvent. Furthermore, solvent usage in CCC is significantly lower (by 10-50%) than that of other preparative chromatography techniques, such as HPLC.

Gentle Technique

CCC is a very gentle technique in which the sample is only in contact with solvents and teflon (or other inert material). Therefore CCC provides the least chance for sample degradation/decomposition.

Versatile Selectivity

Separation of virtually every compound class has been demonstrated with CCC. Selectivity over a full range of polarities is achieved through the use of appropriate CCC Solvent Systems.

Scaleable

CCC is able to range from milligrams to tens of grams on the same instrument. Furthermore, many Manufacturers provide instruments that are capable of producing tons of pure product per year. When GC or HPLC is carried out with large sample loading, resolution is lost due to issues with surface-to-volume ratios and flow dynamics; this is avoided when both phases are liquid.

100% Sample Recovery

Since CCC does not use a solid support, permanent adsorption of analyte onto the column is avoided, and a 100% recovery of the analyte can be achieved in practice.